Coxibs, or selective non-steroidal anti-inflammatory agents in combination with a gastroprotective agents?
Systemic connective tissue disease, many other non-infectious inflammatory processes known to require systematic long period of time, nonsteroidal anti-inflammatory drugs (NSAIDs). Since the risk of their use, the most frequently, gastrointestinal ulceration and bleeding, and there is a problem prevention.
It seemed that the solution was a new class of NSAIDs - the so-called specific NSAIDs or coxibs. Treatment of them, however, expensive. An alternative strategy - instead of coxib use of the same non-selective non-steroidal anti-inflammatory drugs, however, under the cover of gastroprotective agents such as proton pump blockers ions.
Used both strategies. But here's the GMC Masclee colleagues raised the question, all the same, coxibs or non-selective non-steroidal anti-inflammatory drugs in combination with gastroprotective agents?
To solve the problem made case-control study in three European databases of outpatient data from which were selected two groups of patients, respectively, treated with coxibs without cover gastroprotective agents () and non-selective NSAIDs under their protection. The patients in both groups was 50 years.
The results showed the same risk of gastrointestinal complications in both groups of patients, which implies that what therapy to give preference, in many respects depends on the wishes of the patient. Note that using a number of coxibs increased cardiovascular risk.
Wherein authors point out that patients receiving glucocorticoid preparations preferably still, coxibs, since in this case the risk of gastrointestinal complications kieshchnyh less than in the case of nonselective NSAIDs treatment in combination with gastroprotective agents.
All sorts of chronic non-inflammatory processes of the cohort seasonal meteozavisimosti, and more.
Non-steroidal anti-inflammatory drug - Wiki Article
Nonsteroidal anti-inflammatory drugs, usually abbreviated to NSAIDs pron.: /ˈɛnsɛd/ EHN-said—but also referred to as nonsteroidal anti-inflammatory agents/analgesics or nonsteroidal anti-inflammatory medicines —are a class of drugs that provide analgesic and antipyretic effects, and, in higher doses, anti-inflammatory effects.
The term "nonsteroidal" distinguishes these drugs from steroids, which, among a broad range of other effects, have a similar eicosanoid-depressing, anti-inflammatory action. As analgesics, NSAIDs are unusual in that they are non-narcotic.
The most prominent members of this group of drugs are aspirin, ibuprofen, and naproxen, all of which are available over the counter in most countries.
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