Unravel the secrets of longevity?

Unraveled the secret of longevity? Passions around aging. Bugged. Exasperate many. Aging is to be extended?

Or active period of life to be extended? Or maybe just to make life healthier, period? Life, know supplies are examples where interference principle of nature leads to tragic consequences.

Can notice one thing - need a healthy philosophy, or else ...

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Roundworm Caenorhabditis elegans grow old and die within a few weeks, while people in some cases even survive centenary. This suggests that mutations accumulated in the course of evolution, which resulted in the appearance of human life expectancy increased at least 2000 times. For centuries, people have been trying to unravel the secret of longevity, but only recently, scientists have become a little closer to a solution.

For many years, molecular biologists specializing in the mechanisms of regulation of physiological and biochemical processes, ignored issues of aging, because, according to traditional notions associated with the aging of tissue deterioration is the result of a passive process of wear and tear. However, we now know that the aging process, as well as many other biological processes that govern the classical signaling mechanisms and transcription factors. Typically, these mechanisms are identified in the study of small organisms with short duration of life, such as yeast, worms and flies, fruit flies, but most of them are having similar effects on mammals.

The study of these mechanisms and the impact of physiological and environmental factors on their work offers the prospect of creating drugs that slow the aging process rights.

There is a view that attempts to slow down the aging process means certain death from age-related diseases, such as cancer or Alzheimer's disease. However, as the results of scientific research, anti-aging mutations tend to postpone and the beginning of the development of such diseases.

The mechanisms that regulate aging

Many mutations affecting life-prolonging genes encoding receptors of nutrients and proteins involved in the formation of stress responses. With an abundance of food and lack of stress, these genes contribute to the growth of the organism and its reproduction. In unfavorable conditions for the life of the activity of these genes varies: some of them are starting to work actively, while others are blocked.

As a result, the global physiological changes aimed at protecting cells and maintain their livelihoods. This shift not only allows the body to survive the unfavorable period, but also increases the life expectancy.

The most prominent of the factors that increase longevity is calorie diet, as shown in a wide range of organisms ranging from yeast and ending monkeys. This phenomenon was first discovered in experiments on rats conducted in the Great Depression amid fears that chronic malnutrition is fraught with decreasing life expectancy. Initially, experts explain the magic effect of starvation by reducing the rate of accumulation of cellular damage, which are the by-product of normal metabolism. However, well-designed experiments on flies, fruit flies (Mair et al., Demography of dietary restriction and death in Drosophila. Science 301, 1731-1733 (2003)) showed that a low-fat diet leads to a sharp decrease in the mortality rate (number of deaths per day) . This indicates that the effects are the result of acute starvation flowing process.

We now know that in the development of a low calorie diet effects of mechanisms involved recognition nutrients including mediated by proteins such as enzymes and AMP kinase, also related to the class of kinases target of rapamycin (target of rapamycin, TOR), and sirtuins (sirtuins) and hormones insulin and insulin-like growth factor-1 (IGF-1). A surprising finding was the fact that the main role of a mechanism to extend the life of the organism depends on the nature of fasting. For example, experiments in C.elegans showed that three options schemes limiting caloric intake (fasting for a lifetime, feeding through the day and the transition to a low-calorie diet in middle age) to launch a variety of mechanisms with the same end result - an increase in life expectancy.

Life expectancy may increase by many other factors, including chemo-and thermosensor signals (both increase and decrease in ambient temperature) heating, oxidative stress signals to the reproductive system, as well as the decrease in the rate of cellular respiration or translation. In most, and perhaps in all of these cases, the process of increasing life expectancy actively manage specific regulatory proteins.

Aging causes a global weakening of the functions of all body tissues, so at first glance, it looks like an impossible task slowdown. However, experiments on laboratory animals have shown that it does not have to deal separately with each of the manifestations of aging, such as atrophy of muscle tissue, wrinkles, and the accumulation of damaged mitochondria - just change the work of a single gene, and the rest of the body does the rest. In other words, living beings have the potential to live longer than is considered normal.

Insulin and insulin-like growth factor-1

First discovered by scientists from the controls the rate of aging is the signaling mechanism mediated by insulin and insulin-like growth factor-1. Mutation that reduces the activity of the genome C.elegans daf-2 gene encoding a hormone receptor, similar to the insulin receptor and IGF-1 in a mammal, more than twice prolongs the life of the worms. Mutations affecting the activity involved in the signaling mechanism of kinase enzymes: phosphatidylinositol 3-kinase (PI (3) K), AKT-pyruvate dehydrogenase kinase (PDK), also prolongs the life of the organisms.

The most impressive feature of these (and many others), long-lived mutants is their ability to save for a long time all the signs of a young body. Suppression signaling mechanism mediated by insulin and IGF-1 influences life by altering the expression of genes encoding a number of transcription factors (including DAF-16, FOXO, HSF-1 and SKN-1). These factors, in turn, stimulate or inhibit the expression of other genes including those involved in the development of stress reactions provide mechanisms autophagy (processing defective cell fragments for the synthesis of organelles) and encoding antimicrobial peptides chaperone proteins, apolipoproteins, lipase and ion channels.

Cumulative effect of changes taking place at the same time and is the increase in life expectancy. An interesting fact is that the number of genes normally expressed in embryonic cells abnormally expressed in somatic cells daf-2 mutants. Apparently, these genes (at least in part) cause an increase in life expectancy of the body, and a detailed study of their work can give scientists more than one surprise.

For example, the activity of some of these genes in the cells of daf-2 mutants increased twice. While one can only guess what will happen if their activity is increased tenfold.

The Secret of Bulgarian Longevity - HUSSE Pro.test /Riots in Sofia 2013/

Описание:

We shot and edited this video for less than 24 hours during the anti-govt protests in Sofia in the summer of 2013. Please, share/comment if you like it! Thanks for watching
(Make sure you've set the video on HD quality)

WHY BEES DISAPPEAR

Why why bees are disappearing bees disappear, an important question, because for them, the bees can go and people. So broadcast predictors that and say - bees leave the Earth first. Do not believe no-brainer.

Tries to answer the question Marla Spivak.

The living world is very fragile structure, and destroy it just being called unreasonable man.

Time does not think, and did not even make decisions, but to act.

To catch, as in ... last car of the train.

What If the bee disappeared off the surface

Описание:

The problems, and maybe the solution.

The electricity at home that we are using for a while also penetrate the body
Is modulated at 50 or 60 hz.
This modulation has less effect on the systems off the body.
Because owner body works at frequents lower than that 2 till 16 Hz.
Only when it produce a great magnetic field because using power that
Is a problem for owner body. It courses leukaemia.
And it is a terror to owner body but we are doing it for a decade
So maybe we have adapted it .

For us it is very important that we must get owner rest. (sleep)

But what we are doing now is very wrong.
The Gsm, Wimax, Dect, Umts, digital television and so on is a wrong terror system for us.
Because the microwaves are so small that it will penetrate easy in to owner body.
And the are telling that it will only gifs a terminal problem.
But that's not the problem at all.
That limit is measurable and it does not obtain
That's what the telecom industries only is talking about.

There are two big problems:
The first problem is that the modulation is at the same frequents as owner body nerve system frequents.
And its interactive wit it.

We can solve 80% off this problem if we waned to keep using the nice wireless systems.
There are two large errors which we are doing wrong.
Now the transmitters are transmitting non stop day en night.
This is because every micro cell-mark must be transmitted for al the phones to be recognized.
Even when there is no mobile phone around its sends his cell-mark. Here I am.
And because there can be thirty calls true one antenna at ones.
And when the have calculated that the neat 200 calls at that place at ones.
That neat 7 antennas at that place.

And the all transmitting constant.
.Even when there is a neat for only 20 calls .
For example at 4 o clock in the morning when everybody is tries to sleep.

The system is with less cost to change with software.
It must be like this:
The system must be so that always one transmitter sends the beacon. (her I am)
So the mobile phones can now where the are. And can login for accepting his call.
And the system knows where the mobile phone is in the system.
That is how the system is working now.

But only so must transmitters must be switched on for the calls ho are needed.
And no more than that.
For example: When there are less that thirty calls there must be one antenna switched on.
The rest must put and stay off.
And when call 31 has building up transmitter two must be shut on.
And so one and so on.

Problem two is this:
For the Netherlands : We have 5 telecom providers.
So we have 5 systems running.
And the most of them has there own antennas system.
The accept a call from a other provider for example A, but that other provider A then has to pay
that provider B and so on.

Here in Netherlands we have for that case 4 times too much antennas transmitting all the time.
There must be a law that refuses this manner to use the system like this.
I can understand it because off me knowledge off high frequents.
It is a hobby from till I was 9 years old.
But 90 percent off people don't no a thing about this.

It must be so that there are precise and safe places with transmitters and his antennas.
The transmit system.
And the must all use that system together.

And no other way.
And when where are people near by and have too much radiation from that place.
The system must protect those people. And must be a big part off that law.

Every one has the right to live without undesirable influences from others.

In the mine will do research why people getting sick from those microwaves
and his modulation.

IF THE CORE OF OUR GALAXY TO BE ACTIVE AGAIN

If the nucleus of our Galaxy will become active again if the core of our Milky Way galaxy will become active again, systems and planets that close, it's hot not find it.

Scientists from the University of Sydney (Australia), led by Joss Bland-Hawthorne (Joss Bland-Hawthorn), argue that defined the time when a supermassive black hole (SMCHD) at the center of our galaxy is not hiding, and, like many other SMCHD, illuminated Milky Way, throwing bright relativistic jets of matter, accelerated to enormous speeds, up and down from the galactic disk.

Vicinity of the black hole Sagittarius A * eyes Very Large Telescope (illustration ESO, VLT).

Typically, the galaxy in which something like this happens to resemble a Christmas tree in a dull night: they can be seen from afar. It is active nuclei of galaxies were the first objects that humanity is found at a distance of billions of light years. Absorbing material, the black hole heats it to the point that it glows, and it emitted jets form along the length of a whopping huge glowing object brightness.

Several years ago, the results of observations of gamma-ray telescopes have indicated that up and down from the Galaxy have bubbles (sometimes referred to as Fermi bubbles on the name of their discoverer telescope), ending a 25-thousand light-years from the galactic disk.

Immediately after that, there was the theory that the bubbles - it traces the outbreak in the region of Sagittarius A *, accompanied by jets and the emission of matter, plasma, which is the current barely discernible boundaries of the bladder. But when did this happen? Flash duration, based on the experience of observations of other galaxies, more or less clear: to hundreds of thousands of years. With the date worse.

The situation is bad bladder wall prompter, astronomers have known that the ejection of matter from the surrounding area SMCHD can go with a completely different speeds.

Mr. Bland-Hawthorn, just hearing about bubbles, decided that such a flash in the past Sagittarius A * could remove another long-standing puzzle. In 1996, astronomers discovered that part of the Magellanic Stream (a fast-moving stream of hydrogen at 240 thousand light-years from the Milky Way, the entire disk which has a diameter of about 100 thousand light years) goes much stronger than the rest of the material of the object. Maybe it's in the bubbles Fermi?

After all, this is the brightest part is below the galactic center, it would have to be in front of the flash ...

After reviewing their interesting part of the Magellanic Stream, astronomers have decided that it is caused by an unusual glow intense ultraviolet radiation, which is part of the ionized gas flow. It is interesting that the experience of observing other galaxies with an active nucleus are known to emit very bright in the UV range.

By calculating the time in which ultraviolet light from the nucleus could reach the glowing part of the stream and ionize it, and how long the flood light then get to us, the scientists, as they feel able to very accurately date the event - the last severe outbreak in the region of Sagittarius A * .

So, it was relatively recently - about two million years ago. That is, all these Homo Habilis and even the first Homo Erectus, extinct 30 thousand years ago, it could see in the sky an unusual sight as an active galactic nucleus night light is not worse than the Moon:

The work is interesting not only because we are familiar with the details of the device during the night lighting Olduvai culture. The idea of some theorists that active galactic nuclei could arise only in mergers with another galaxy (due to the receipt of additional mass of dust and gas), and, therefore, the flash - a very rare event, pretty much called into question: does not seem to a couple of million years ago, the Milky Way merged with something ...

Far below the active core of the Milky Way a couple of million years ago was the Magellanic Stream, part of which is still glowing from the then-radiation from the vicinity of Sagittarius A *. (Illustration New Scientist.)

In contrast, recent ideas other theorists that flashes can occur as the cooling gas in the areas far from the galactic nucleus and its drift towards the center to give indirect.

Incidentally, all this also means that the core of our Galaxy can become active again, and at any time. Of course, for the inhabitants of nearby planets it will be a deadly spectacle, but in this case we were not in danger: We will protect a distance of a quarter of hundreds of thousands of light years. Another thing is that the concept of the so-called galactic habitable zone is filled with new meaning: if the cleaning of all living things in the nucleus of the galaxy do happen every few million years, the civilization there will be difficult.

With preprint considered work can be found here.

 in the wake of NewScientist, Shutterstock, compulenta.computerra.ru

Samsung Galaxy S4 Active Sneak Peek

Описание:

Here's a quick video peek from an informant at the Samsung Galaxy S4 Active Android smartphone. Not yet officially announced, the S4 Active comes to us via a source who got his hands on the device overseas (this is a leak, not a review). The S4 Active GT-19295 has a 1.9GHz quad core CPU according to Samsung (our reporter was initially told it had a dual core but thankfully that's not the case), an 8MP rear camera with all the features found on the standard Galaxy S4 and a dust-proof and waterproof design. The remaining specs are the same as the non-rugged GS4 like the 5" full HD display.
Watch our video review of the release Galaxy S4 Active: http://youtu.be/SUgmvFKp_Qs