Immune deficiency will be treated by immunosuppressive drugs or Hahnemann
In the U.S., the researchers came to the conclusion that the innate immune deficiency can be cured immunosuppressant. In this case, the scientists had to deal with quite a rare species of immune deficiency, which causes a mutation in the gene encoding the enzyme P110, involved in immune response.
As a result of mutations in patients with increased enzyme activity. It would seem that they were therefore have a stronger immunity, but in reality it was the opposite.
Experts from the National Institutes of Health in Betecde led GULBAKH Uzel investigated 14 people from seven families in age from 1 to 40 years. These people are constantly suffering from lung infections. All of the subjects found a mutation in the gene encoding the enzyme P110. It turned out that these people have been deprived of the lion's share of T-cell memory.
These cells help to see which organism infections are encountered, to respond quickly in case of a new appointment.
On the surface of T cells are the receptors that are able to recognize specially antigens present in the body, often - fragments of infectious agents. Learning antigen, lymphocyte begins to actively share in the blood and excrete special substances - cytokines that activate other cells of the immune system that can kill foreign cells that cause the activation of T-lymphocytes.
The researchers decided to use the drug rapamycin, known as an immunosuppressant. Usually it is used in transplantation to reduce the rejection of transplanted organs. Name of rapamycin was due to the fact that was first isolated from bacteria discovered on Easter Island (Rapa Nui).
Use of rapamycin helped to offset the excessive activity of the enzyme P110. The drug thus removes the disruption of white blood cells: excessive proliferation and increased survival.
in the wake of Dominant-activating germline mutations in the gene encoding the PI (3) K catalytic subunit p110delta result in T cell senescence and human immunodeficiency, vechnayamolodost.ru
